Juan L. Bruses
- Professor, Biology
- School of Health and Natural Sciences
- Library 139N
- jbruses@mercy.edu
- (914) 674-7379
Dr. Brus茅s received his PhD in neurobiology from the University of Buenos Aires (UBA) and conducted postdoctoral training at the University of Connecticut (UCONN) and at Case Western Reserve University (CWRU). Thereafter, he worked as a senior Scientist at the Sloan-Kettering Institute (MSKCC, SKI) in New York City. His research focuses on the role of cell adhesion molecules in neural development. He currently teaches Molecular and Cell Biology, Neuroscience, and Independent research. He is the Director of the National Science Foundation (NSF) funded Research for Undergraduate (REU) in Neuroscience summer program in collaboration with Albert Einstein Medical College.
Ph.D., Neurobiology, School of Medicine, University of Buenos Aires (UBA)
Postdoctoral Training, Department of Physiology and Neurobiology, University of Connecticut (UCONN); Department of Genetics, Case Western Reserve University (CWRU)
Dr. Bruses research focuses on the role of cell adhesion molecules in neural development. His interest focuses on the role of the cadherins and immunoglobulins superfamilies of adhesion molecules on the formation of synaptic contacts and on the changes of these molecules throughout evolution.
BIOL 275 Cell Biology
BIOL 317 Introduction to Neuroscience
BIOL 355 Molecular Biology of the Cell
BIOL 370 Research in Biology
BIOL 424 Neurobiology
BIOL 460 Coordinating Seminar in Biology (Capstone Research Section)
In peer-reviewed journals
Polanco J, Reyes-Vigil F, Weisberg S, Dhimitruka I, Bruses JL (2021) Differential spatiotemporal expression of type I and type II cadherins associated with the segmentation of the central nervous system and formation of brain nuclei in the developing mouse. Front Mol Neurosci 14: 633719
Daghsni M, Rima M, Lopez A, Fajloun Z, Ronjat M, Bruses JL, M鈥橰ad R, De Waard M (2018) Autism throughout genetics: perusal of the implication of ion channels. Brain and Behavior 3: 1-18.
Rima M, Daghsni M, Lopez A, Fajloun Z, Lefrancois L, Dunach M, Mori Y, Merle P, Bruses JL, De Waard M, Ronjat M. (2017) Down-regulation of the Wnt/尾-catenin signaling pathway by Cacnb4. Mol Biol Cell
Rima M, Daghsni M, De Waard S, Gaborit N, Fajloun Z, Ronjat M, Mori Y, Bruses JL, De Waard M (2017) The 尾4 subunit of the voltage-gated calcium channel (Cacnb4) regulates the rate of cell proliferation in Chinese Hamster Ovary cells. Internat. J. Biochem Cell Biol 89:57-70
Rima M, Daghsni M, M鈥橰ad R, Fajloun Z, Bruses JL, Ronjat M, De Waard M (2016). Protein partners of the calcium channel beta subunit highlight new cellular functions. Biochemical J 473:1831-1844
Rousset M, Cens T, Menard C, Bowerman M, Bellis M, Bruses JL, Raoul C, Scamps F, and Charnet P (2015). Regulation of neuronal high-voltage activated CaV2 Ca2+ channels by the small GTPase RhoA. Neuropharmacology 97:201-209
Bruses JL (2013) Cell surface localization of alpha3 beta4 nicotinic acetylcholine receptors is regulated by N-cadherin homotypic binding and actomyosin contractility. PLOS One 8:e62435
Arrode-Bruses G, Bruses JL (2012) Maternal immune activation by poly(I:C) induces expression of the cytokines IL-1beta and IL-13, chemokine MCP-1, and colony stimulating factor VEGF in fetal mouse brain. J Neuroinflammation 9:83-98
Flannery R, Bruses JL (2012) N-cadherin induces partial differentiation of presynaptic terminals in heterologous cultures of brain stem cholinergic neurons and CHO cells. Frontiers in Neuroscience 4 (article 6): 1-11
Zelenchuck TA and Bruses JL (2011) In vivo labeling of zebrafish spinal cord motor neurons using an mnx1 enhancer and Gal4/UAS. Genesis 49:564-554
Bruses JL (2011). N-cadherin regulates primary motor axons growth and branching during zebrafish embryonic development. J Comparative Neurology 519:1797-1814
Bruses JL (2010) Identification of gene transcripts expressed by postsynaptic neurons during the initiation of synapse formation encoding cell surface proteins with presumptive synaptogenic activity. Synapse 64:47-60
Marrs GS, Theisen CS, Bruses JL (2009) N-cadherin modulates voltage-activated calcium influx via RhoA, p120-catenin, and myosin-actin interaction. Molecular Cellular Neuroscience 40:390-400
Rubio ME, Curcio C, Chauvet N, Bruses JL (2005) Assembly of the N-cadherin adhesion complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1. Molecular Cellular Neuroscience 30:118-130
Tricaud N, Perrin C, Bruses JL, Rutishuaser U, (2005) Adherens junctions in myelinating Schwann cells stabilize Schmidt-Lanterman incisures via recruitment of p120 catenin to E-cadherin. J Neuroscience 25:3259-3269
Piccoli G, Rutishauser U, Bruses JL (2004) N-cadherin juxtamembrane domain modulates voltage-gated Ca2+ current via RhoA GTPase and Rho associated kinase. J Neuroscience 24:10918-10923
Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses JL, Topf N, Harrison NL, Studer L (2004) Derivation of midbrain dopamine neurons from human embryonic stem cells. Proceedings National Academy Science USA 101:12543-12548
Barberi T, Klivenyi P, Calingasan NY, Lee H, Kawamata H, Loonam K, Perrier AL, Bruses JL, Rubio ME, Topf N, Tabar V, Harrison NL, Beal MF, Moore MA, Studer L (2003) Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nature Biotechnology 21:1200-1207
Bruses JL, Chauvet N, Rubio ME, Rutishauser U (2002) Polysialic acid and the formation of oculomotor synapses on chick ciliary neurons. J Comparative Neurology 446:244-256
Fujimoto I, Bruses JL, Rutishauser U (2001) Regulation of cell adhesion by polysialic acid. Effects on cadherin, immunoglobulin cell adhesion molecule, and integrin function and independence from neural cell adhesion molecule binding or signaling activity. J Biological Chemistry 276:31745-31751
Bruses JL, Chauvet N, Rutishauser U (2001) Membrane lipid rafts are necessary for the maintenance of the (alpha)7 nicotinic acetylcholine receptor in somatic spines of ciliary neurons. J Neuroscience 21:504-512
Bruses JL, Rutishauser U (1998) Regulation of neural cell adhesion molecule polysialylation: evidence for nontranscriptional control and sensitivity to an intracellular pool of calcium. J Cell Biology 140:1177-1186
Bruses JL, Oka S, Rutishauser U (1995) NCAM-associated polysialic acid on ciliary ganglion neurons is regulated by polysialytransferase levels and interaction with muscle. J Neuroscience 15:8310-8319
Oka S, Bruses JL, Nelson RW, Rutishauser U (1995) Properties and developmental regulation of polysialyltransferase activity in the chicken embryo brain. J Biological Chemistry 270:19357-19363
Bruses JL, Pilar GR (1995) Effect of cycloheximide and mRNA synthesis inhibition on death of trophically deprived ciliary ganglion neurons in culture. J Neurophysiology 74:2487-2499
Bruses JL, Capaso J, Katz E, Pilar G (1993) Specific in vitro biological activity of snake venom myotoxins. J Neurochemistry 60:1030-1042
Gray DB, Bruses JL, Pilar GR (1992) Developmental switch in the pharmacology of Ca2+ channels coupled to acetylcholine release. Neuron 8:715-724
Bruses JL, Berninsone PM, Ojea SI, Azcurra JM (1991) The circling training rat model as a behavioral teratology test. Pharmacology Biochemistry Behavior 38:739-745
Berninsone PM, Bruses JL, Azcurra JM (1989) Detection of drug effects on neurons: protein synthesis inhibition by low doses of amphetamine. Methods and Findings in Experimental and Clinical Pharmacology 11:249-253
Invited book chapters and reviews
Bruses JL (2010) N-cadherin regulation of synapse formation and synaptic activity. In 鈥淢olecular and Functional Diversities of Cadherin/Protocadherin鈥. Edited by K. Yoshiuda, Research Signpost, Chapter 3 pp 39-55
Bruses JL (2006) N-cadherin signaling in synapse formation and neuronal physiology. Molecular Neurobiology 33:237-252. PMID: 16954598
Bruses JL, Rutishauser U (2001) Roles, regulation, and mechanism of polysialic acid function during neural development. Biochimie 83:635-643. PMID: 11522392
Bruses JL, Rutishauser U (2000) Regulatory Roles of Polysialic Acid in Neural Cell Development. In Molecular and Cellular Glycobiology: Frontiers in Molecular Biology. Ed. M. Fukuda and O. Hindsgaul. Oxford University Press pp116-132
Bruses JL (2000) Cadherin-mediated adhesion at the interneuronal synapse. Current Opinion Cell Biology 12:593-597. PMID: 10978895
Bruses JL (2000) Regulacion de la adhesion celular durante la formacion de sinapsis: interacciones funcionales entre N-cadherin, p120ctn, y acido polisialico. Serie 鈥淪eminarios del Instituto de Biolog铆a Celular Dr. Eduardo De Robertis鈥
Bruses JL, Azcurra JM (1993) The Circling Training: A Behavioral Paradigm for Functional Teratology Testing. In Methods in Neuroscience Vol. 14, Paradigms for the Study of Behavior. Ed P. M. Conn. Academic Press pp 166-179
Books
Donnoli VF, Moroni MV, Bruses JL (2015). Esquizofrenia Unica: Clinica, Psicopatologia, Neurobiologia. Ed. Salerno, Buenos Aires, Argentina ISBN 978-987-9083-49-9
Active
- National Science Foundation (NSF) - Research Experience for Undergraduates (REU) 2020 -2022. PI: Bruses JL; Co-PI Pena JL
Title: REU Site: Summer Research Experiences in Neuroscience
Collaborative project between Mercy College Department of Natural Sciences and AlbertEinstein Department of Neuroscience
Amount: $416,349
- Faculty Development Course Release Award, Mercy College Provost鈥檚 Office
PI: Bruses JL, Title: Type II cadherins in neural development, Fall semester 2021
Completed
- R01 NS40300, NIH/NINDS, PI: Bruses JL 2001 - 2007. Title: Cell-cell interactions in synapse formation and function.
- Michael J Fox Foundation for Parkinson Research PI: Studer L, Co-PI: Bruses JL 2002 - 2004. Title: Unlimited numbers of midbrain dopamine from human embryonic stem cells
- Faculty Development Award, PI: Bruses JL, 2005 鈥2006, Center of Excellence for Minority Medical Education Health and Human Services
- Faculty Recruitment Award NIH/KIMBRE, PI: Bruses JL, 2005 鈥2006
- Lied Endowment / KUMC Research Institute, PI: Bruses JL, 2007 鈥2008. Title: N-cadherin regulation of neuronal physiology during development
- Kansas City Area Life Science Institute, PI: Bruses JL Co-PI: Chandrasekhar A, 2007 鈥2008. Title: Role of N-cadherin in neuronal and synaptic patterning
- KIMBRE Pilot project NIH / KIMBRE, PI: Bruses JL 2008 - 2008. Title: Cell adhesion receptors in neuromuscular development
- Pilot Research Grant NIH / KIMBRE, PI: Bruses JL, 1/1/2009 - 12/31/2009. Title: Analysis of N-cadherin signaling in neurons
- Pilot Research Grant NIH / COBRE, PI: Bruses JL 2008 鈥2010. Title: Identification and characterization of synaptogenic proteins
- R21 MH082245, NIH/NIMH, PI: Bruses JL 2009 - 2011. Title: Isolation and characterization of synaptogenic proteins
- T32 HD057850, NIH/H, DPI: Nudo RJ 2009 - 2014. Training Program in Neurological and Rehabilitation Sciences
- Discovery Grant Award, PI: Bruses JL, 2010 - 2011. Kansas Center for Autism Research and Training (KCART) Title: Effect of perinatal immune challenge on brain cytokine levels and animal behavior
- Mercy Travel Award to attend the 2014 Annual Meeting of the American Society for Cell Biology
- Mercy Travel Award to attend the 2015 Gordon Research Conference in Cell Contact and Adhesion
- Faculty Development Award, Mercy College Provost鈥檚 Office 2015
PI: Bruses JL; Title: Regulation of 伪3尾4 Nicotinic Acetylcholine Receptor (nAChR) Expression and Localization by the Actin Cytoskeleton; Direct cost: $2998.25
- Mercy Travel Award to attend the 2016 Annual Meeting of the American Society for Cell Biology
- Faculty Development Course Release Award, Mercy College Provost鈥檚 Office 2016
PI: Bruses JL; Title: Regulation of nicotinic acetylcholine receptor expression and localization, Fall semester 2016
- Faculty Development Award, Mercy College Provost鈥檚 Office 2017
PI: Bruses JL; Title: Cell contact-mediated regulation of nicotinic acetylcholine receptors (nAChR) on the cell surface. Direct cost: $2368, Fall semester 2017
- MAC Linkage Fellow grant from the American Society for Cell Biology (ASCB) 2018
PI: Bruses JL. This grant is to support activities to increase scholarship and interest in cell biology. The activities supported by this grant include Research Seminar Series, Science Caf茅 and Journal Club. Direct cost: $5,000
- Faculty Development Course Release Award, Mercy College Provost鈥檚 Office 2018
PI: Bruses JL, Title: Regulation of nicotinic acetylcholine receptor expression and localization, Fall semester 2018
- Faculty Development Course Release Award, Mercy College Provost鈥檚 Office 2019
PI: Bruses JL, Title: Regulation of nicotinic acetylcholine receptor expression and localization, Fall semester 2019